Conditions include alcoholic liver disease, viral hepatitis, cirrhosis, and primary or metastatic liver cancer Renal dysfunction : Impaired kidney function reduces B12 elimination, causing accumulation even with normal intake Haematological conditions : Myeloproliferative neoplasms, chronic myeloid leukaemia, polycythaemia vera, and hypereosinophilic syndrome increase transcobalamin production, elevating total serum B12 Laboratory interference : Macro-B12 (immunoglobulin-bound B12) and assay interference can cause spuriously elevated results without true excess In clinical practice, unexplained hypercobalaminaemia should prompt investigation for underlying disease, particularly in patients without obvious supplementation history
Interestingly, in cats, there was no change in serum concentrations of homocysteine (see Figure 1)
Just because our bodies make peptides does not mean that injecting yourself with one specific peptide will give you health benefits. To find out more, host Lexy Lebsack sat down with these two experts on the topic
LGC Limited
B12 is an essential vitamin that the body needs to function properly