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A healthy rise in both typically indicates: Good GH stimulation Functional liver response Controlled anabolic tone But if IGF-1 spikes and IGFBP-3 remains low, the result may be excessive free IGF-1, a red flag for cancer risk or overgrowth signaling
In contrast, its intestinal microbial metabolite, urolithin, possesses better biological activity and higher bioavailability [173]
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