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You can set this up in the first few turns with Queen first, Nick Wilde Sly Fox Sleuth and the Queen damage ability on turn two, into Pluto turn three to play Queen again, setting you up for something similar turn four

Counter Blitz: Boost team spirit by moving counters from creature to creature

Unholy Annex deals 2 damage to you each turn, but if you control demons (or changelings), then it becomes a future win condition

The power level of the Dominus and Twilight cycles, matched with the speed boost games will get from an increased presence of poison counters, means that this set is going to have a huge impact on Commander

This is especially important since the most popular partner commander is Vial Smasher the Fierce, which is also red