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It isnt like in Extended where Ghost Quarter can swat off an entire Dark Depths deck

Your opponent just got two-for-one card advantage (your creature and your Dragonscale Boon for his or her Throttle) and also got tempo advantage from removing a creature from the board while you spent your mana accomplishing nothing

Blighted Agent is as scary as ever, of course

From commanders like Astarion, the Decadent and Blitzwing, Cruel Tormentor, enablers like Wound Reflection, to the various Sanguine Bond/Exquisite Blood style loops now available, Shredder is a must-block

This can rocket your curve up if you get it when you need to and even late in the game its a great blocker