The game focuses on Duel Monsters deck building with a large card pool and Structure Deck content from Dragons Roar through Spellcasters Judgment.
Yes, the actual play in game is key, but theres simply too much in the format to know by heart for one duelist to prepare for, so instead its best to arrive at a given duel with the best version of a strategy that you can

Abdel Adrian, Gorion's Ward Achilles Davenport Acolyte of Bahamut Agent of the Iron Throne Agent of the Shadow Thieves Ainok Strike Leader Akroma's Will Akroma's Will Alora, Merry Thief Amber Gristle O'Maul Aminatou, the Fateshifter Ancestral Communion Angelic Field Marshal Archivist of Gondor Astarion's Thirst Baeloth Barrityl, Entertainer Bane's Contingency Bastion Protector Benalish Commander Biowaste Blob Bloodsworn Steward Brotherhood Ambushers Burakos, Party Leader Candlekeep Sage Captain Vargus Wrath Chain Assassination Clan Crafter Clara Oswald Cloakwood Hermit Cloudkill Command Beacon Command Beacon Commander Greven il-Vec Commander Sofia Daguerre Commander's Insight Commander's Insignia Commander's Plate Commodore Guff Company Commander Convergence of Dominion Criminal Past Crimson Honor Guard Cultist of the Absolute Daretti, Scrap Savant Deadly Rollick Deflecting Swat Demon of Wailing Agonies Dihada, Binder of Wills Distract the Guards Dragon Cultist Drillworks Mole Drown in Dreams Dungeon Delver Durnan of the Yawning Portal Eagle Vision Echo Storm Ellyn Harbreeze, Busybody Elminster Empyrial Storm Endless Ranks of HYDRA Erinis, Gloom Stalker Escape Detection Estrid, the Masked Everett K

Some cards recover over time, but others remain lower once a cheaper version is available
For now, constructed play is made up of the following sets: Fabled Whispers in the Well Winterspell Wilds Unknown Attack of the Vine Hyperia City As a tease for the next Disney Lorcana set, which we already know is called Hyperia City and will focus on the Coco film, we have a confirmed release date of October 23, 2026, with prerelease starting one week earlier on October 23