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Cards like Tandem Lookout and Keen Sense allow you to draw cards when Niv-Mizzet deals damage, allowing you to draw more cards, then deal more damage, and then draw more cards until the opponent has no life

An example result from the art generator for the Mirror Shell Wyvern

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As noted, you can only use one Supporter card per turn, and this is thanks to their greater immediate potential to cause a more drastic positive shift for you

If an Adventure spell leaves the stack in any way other than resolving (most likely by being countered or by failing to resolve because its targets have all become illegal), that card won't be exiled and the spell's controller won't be able to cast it as a permanent later