what does the world card do in binding of isaac Isaac: Four Souls Requiem XXI. The World - Four

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So far, this hasnt happened, so demand for Rhystic Study remains consistently high

Doing so early on can give one enough energy to play big strategies right out of the gate before the opponent can do anything about it

while he no longer can be healed by conventional means, his Elder Sign gains the ability to dump some damage/horror (depending on which version is used) on his assets, which can be healed or at least replaced with new ones

If a deck contains four copies of a single card (the maximum), just that one card would bring the price of a deck up by $100