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Demographic, Behavioral, and Clinical Characteristics of Persons Seeking Care at Sexually Transmitted Disease Clinics - 14 Sites, STD Surveillance Network, United States, 2010-2018
Androgens have been shown to downregulate the expression of bile-salt export pump (BSEP) and multidrug resistanceassociated proteins (MRPs), resulting in bile-acid retention and cytotoxic accumulation within hepatocytes
Direct answer: It is generally not recommended for routine use in the first trimester
This effect results from delayed gastric emptying and central nervous system effects on appetite regulation centres
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