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First, under normal conditions, elevated HO1 expression attenuates oxidative stress to exert cytoprotective effects, and second, sustained HO1 upregulation releases ferrous iron to exacerbate oxidative stress, which leads to ROS accumulation through the Fenton reaction
Concentrated virus was added to day 2 cultured CD34+ erythroid progenitors in the presence of 8 g/ml polybrene
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While supplementation may provide symptomatic benefits, an appropriate dosage has yet to be determined
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