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Ice crystal formation can physically damage the peptide structure
This is also where the supply-versus-stability point from the reconstitution section bites: if a reconstituted 10 mg vial holds ~66 doses but the solution is only reliably stable for a few weeks, plan the reconstitution volume so you are not left discarding drug you paid for
working on medicinal chemistry of peptides - I strongly agree with Eric Topol, MD
A few more data points are worth keeping in view because they round out the safety story
Thats exactly why some folks are excited about cagrilintide: It may boost the effectiveness of semaglutide by activating a second pathway (amylin) that helps you feel full at the same time semaglutide is activating its own (GLP-1), instead of competing for the same one
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