extreme fatigue on semaglutide Fatigue: Feeling Weak Semaglutide Feeling Weak on Semaglutide: Causes

Wankhede N, Kale M, Shukla M, Nathiya D, Kaur P

A consistent theme across conference discussions at ASN 2025 reinforced that kidney care is becoming more multidisciplinary, and GLP-1 therapies are helping to quietly accelerate that transition

These drugs mimic the physiological effects of GLP-1 by binding to GLP-1R, which enhances insulin secretion, inhibits glucagon release, delays gastric emptying, and reduces food intake (Figure 1B)

Diabetes 38(1):716

In any case, the shift towards oral drugs provides a significant demand tailwind for CDMOs, given the much higher API requirements (due to lower bioavailability)