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For people with malabsorption issues , the difference is dramatic

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drinking water consistently throughout injection day reduces both nausea intensity and orthostatic hypotension episodes

2 Agents that follow a different metabolic pathway, such as triazolam, alprazolam, clonazepam, and lorazepam, have poor cross-reactivity with the assay due to the absence of these metabolites and thus frequently produce false-negative results

However, additional studies would be necessary to validate these conclusions