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9,12 Additionally, GLP-1RAs activate nitric oxide (NO) synthase expressed in Schlemms canal and the trabecular meshwork, increasing NO production to reduce trabecular meshwork contraction, improving aqueous outflow
Nutritional solutions are increasingly required to mitigate side effects such as muscle loss, which affects over 40% of GLP-1 users
J Am Soc Nephrol 31:21842192
Important interactions include warfarin (monitor INR more frequently), levothyroxine (separate by at least four hours), and ciclosporin (avoid concurrent use)
Ricci DA, Saltzman MB, Meyer C et al
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