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Key safety observations from Phase 2 data include: Gastrointestinal side effects were the most commonly reported adverse events Dose-dependent tolerability issues were noted, particularly at higher doses, with meaningful discontinuation rates Increases in heart rate were observed, consistent with the known class effect of GLP-1 receptor agonists
Furthermore, NSPT ameliorated systemic inflammation by decreasing pro-inflammatory cytokines (IL-6, TNF-, IL-1) and enhancing intestinal barrier integrity via upregulation of tight junction proteins (ZO-1, Occludin)
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