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Reduction of cholesterol with berberine is related to the induction of LDL receptor (LDLR) expression in liver, which may be due to extended half-life of LDLR mRNA via activation of extracellular signal-regulated kinases (ERK) by berberine
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As demonstrated by MP0250 28 , the therapeutic protein's half-lives can be significantly extended by genetically fusing non-HSA-binding DARPins or other therapeutic proteins to albumin-binding DARPins
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