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Where the standard threshold for obesity is 30, the WHO suggests 27.5 for Asian populations
Tolerability varies between individuals and treatment options
32,33 However, given the lack of comprehensive reviews in the existing literature on the pharmacokinetics and drug-drug interactions (DDIs) of GLP-1 RAs and a dual GLP-1/GIP RA, we produced this review to consolidate current knowledge and provide a thorough analysis of key considerations in clinical practice
Both the combined results of the IVW method (OR common-effect-model = 0.43 [95%CI 0.260.72], OR random-effects-model = 0.42 [95%CI 0.240.76]) and the SMR method (OR common-effect-model = 0.97 [95%CI 0.960.99], OR random-effects-model = 0.97 [95%CI 0.951.00]) showed the consistent trend with the separate results(Fig
doi: 10.1038/nature21363 66 ForouhiNGHardingAHAllisonMSandhuMSWelchALubenRet al
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