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The requirements of statistical analyses determined the total number of animals used, the Three Rs (3Rs), and the ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments)
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The released drug molecules can then exert their therapeutic effects, such as inducing apoptosis in cancer cells
A compound that stimulates multiple pathways may look more powerful, but it can also make it harder to isolate what caused the observed outcome
The extrinsic pathway is initiated by the binding of extracellular signals with transmembrane death receptors which directly recruits and activates caspases (101)
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