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doi: 10.1016/j.ccell.2014.09.006 210 KoelfatKVvan MierloKMLodewickTMBloemenJGvan der KroftGAmygdalosIet al

Anyone wishing to study the combined action of GIP, GLP-1, and glucagon within the same molecule cannot avoid a peptidic, injectable approach, since this receptor breadth has so far not been translatable into an oral small-molecule form

It may affect which weight loss medications you can use

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The combination of hormonal changes, reduced physical activity, potential iron supplementation, and GLP-1-related slowed digestion creates a perfect storm for gastrointestinal discomfort