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The restraints were derived from (i) NOE restraints from intermolecular and intramolecular cross-peaks in NOESY spectra (described in NMR spectroscopy section), (ii) TALOS derived p53 TAD2 and FOXO4-DRI backbone dihedral angles, (iii) hydrogen bond restraints (regions p53 residues 4752, FOXO4-DRI residues 918
Given the novel mechanism of this drug, these findings raise the possibility that it could have broader application across other tumour types, he added
Nutrient deficiencies can result from poor food choices, which could hinder overall health, including strong bones, immune health, maintaining strength, and more
& Naylor, R
& Juan, S
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