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Both human [87] and mouse studies [88, 89] demonstrated that a Plin1 deficiency enhanced ectopic fat distribution and impaired insulin sensitivity

[24] Seek medical care if swelling, rash, or systemic symptoms develop

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Management approaches include increasing fiber intake gradually (too much fiber at once worsens bloating), drinking at least 64 ounces of water daily, taking magnesium citrate (400-600mg at bedtime), and increasing physical activity

These injections may also reduce feelings of hunger and cravings, which can make it easier for patients to stick to their diet and exercise plan