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Blood pressure regulation through the nitric oxide signaling pathway represents a systemic vascular effect, with hypotensive activity observed in some animal experiments at higher doses
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Compared with liposomes or polymeric nanoparticles, nanogels often offer superior loading capacity, stability and responsiveness, but design variablespolymer type, crosslink density, particle size and surface chargemust be optimized to avoid burst release and to preserve microbial viability during encapsulation [144]
Importantly, this framework does not assume universal deficiency during GLP-1RA therapy
