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A pilot trial of metformin for insulin resistance and mood disturbances in adolescent and adult women with polycystic ovary syndrome

Proper consultation significantly reduces risks

Funding The author(s) declare that financial support was received for the research and/or publication of this article

The pathophysiology of SCD is complex, involving endothelial activation, BBB disruption, and altered cerebral blood flow dynamics, all driven by chronic inflammation, oxidative stress, and recurrent vaso-occlusive events [195, 196]