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Final Thoughts GLP-1s are powerful

We found that, of the 12 GLP-1 [drugs] identified by our search, the greatest mean body weight reduction was reported in randomized controlled trials of retatrutide, tirzepatide, and semaglutide, the researchers wrote in their paper, published Tuesday in the Annals of Internal Medicine

The research demonstrated that CD4+ T cells are responsible for neurodegeneration, as CD4+ T lymphocytes have been found as key mediators in dopaminergic neuronal death in the MPTP mouse model of PD (66)

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