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While exenatide provides clinically meaningful glycemic control, its impact on weight loss is relatively modest compared to more recent GLP-1R agents, resulting in less than 3 kg of weight reduction over a 30-week period (Min et al., 2025) necessitates twice-daily injections to maintain efficacy, which can be a limiting factor for long-term patient adherence
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In Europe, ALA has been used for years to offer relief from the pain, burning, tingling, and numbing caused by diabetic neuropathy
3 The American Academy of Pediatrics recommends considering pharmacotherapy for adolescents with obesity, but the introduction of potent medications (eg, GLP-1 receptor agonists) presents a host of complex psychosocial and financial questions that extend beyond clinical efficacy
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