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Need for Clinical Trials: Despite promising findings, the authors stress the need for clinical trials to further evaluate semaglutides effectiveness for smoking cessation, as current study limitations do not justify off-label use for this purpose

Activation of GLP-1R induces an increase in intracellular Ca 2+ in 40% of NTS astrocytes, while selective inhibition of astrocyte function in NTS abolishes exendin-4-induced inhibition of food intake (Reiner et al., 2016)

Typically, most patients will need 3-5 sessions about a month apart for the best results

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