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A pivotal 2014 study published in Pediatrics investigated adolescents with vasovagal syncope and POTS

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reported that LDH inhibition rewired IL-2-induced effector-like metabolism, promoted pyruvate entry into the TCA cycle and subsequent OXPHOS, and suppressed the expression of IL-21-induced exhaustion markers, enhancing the formation of stem cell memory T cells (T SCM ) and augmenting antitumor immune responses [296]