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J Neurodev Disord 12:37

By the time there was pain or obvious problems, significant bone was already lost

Potashkin J, Huang X, Becker C, et al

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In a clinical trial in pediatric patients aged 12 years and older with normal baseline heart rate, more patients treated with this drug compared to placebo had maximum changes in heart rate of 20 bpm or more (54% vs 39%)