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Metastatic heterogeneity of breast cancer: molecular mechanism and potential therapeutic targets
This system is highly expressed in astrocytes, the main GSH synthesizing cells in the brain, and is regulated by various factors, including oxidative stress and inflammatory cytokines Once synthesized, GSH can be metabolized by various enzymes, including glutathione S-transferases (GSTs), which conjugate GSH with xenobiotics and endogenous electrophiles for elimination, and gamma-glutamyl transpeptidase (GGT), which cleaves GSH into its constituent amino acids and generates extracellular glutamate, a major neurotransmitter in the brain
Side effects may still occur and vary by patient 4
Conflict of interest The author declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest
Do not adjust injection frequency without speaking with a licensed healthcare provider
