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Meanwhile, in vivo studies revealed that compound 58 (Figure 7) exhibited efficacy comparable to sitagliptin at a dosage of 10 mg/kg
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Lu et al., 2017)
The study aims to clarify the structural and functional aspects of how this antivitamin interacts with CblC, which is crucial for converting vitamin B12 into its active forms
It is typically administered via subcutaneous injection once weekly, with doses gradually increasing over several weeks to enhance tolerability and efficacy
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