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Tirzepatide is a 39-amino-acid peptide with a fatty acid sidechain (a C20 icosanoyl moiety) that makes it sensitive to agitation-induced aggregation
Researchers at the University of Arizona modified alpha-MSH in the 1980s and 1990s to produce more potent, longer-acting compounds
PMID: 32842827, PMCID: PMC7904961, DOI: 10.1177/0733464820950125
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