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In Alzheimer's disease , a systematic review of 71 US-based Phase 3 trials with published results from 1997 to 2023 found nearly half (49.3%) did not report patient race or ethnicity at all, and among those that did, median White enrollment stood at 91.3% , against median enrollment of just 7.2% for non-Hispanic Black participants and 5.2% for Hispanic participants ( [13] )
Comparison with structures of the AMY 1 R bound to non-lipidated peptides (CagriBB and rAmy) revealed that the lipid conjugation does not affect the conformation of the peptide, nor the receptor when Cagri is stably engaged
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A gene expression analysis by Pickart and Margolina (2018, published in Biomolecules ) reported that GHK alone (without copper, as a free peptide) modulated the expression of over 4,000 human genes in a Broad Institute Connectivity Map analysis, including pathways related to inflammation, DNA repair, and antioxidant defense
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