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Meaningful body-weight reductions , though slightly less than in non-diabetic participants a trend also seen with injectable GLP-1 receptor agonists These results show why orforglipron is being closely monitored as a potential long-term oral GLP-1 medication for weight management and metabolic health

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Glucagon receptor activation increases hepatic glucose output and, at doses balanced against GLP-1R-mediated insulin secretion, raises basal metabolic rate by 10 to 20% in preclinical models without net hyperglycemia

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