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Injecting cold solution causes immediate vasoconstriction and sharp, burning pain that persists for several minutes post-injection

doi: 10.1371/journal.pone.0171860 108 GattMEStrahilevitzJSharonNLavieDGoldschmidtNKalishYet al

Experiments with some animal models have revealed that TMAO reduces blood pressure and plasma levels of NT-proBNP in rats and also inflates the left ventricular ejection fraction (LVEF).TMAO has a protein-stabilizing effect and promotes heavy plasmin and actin complexes, increasing myocardial contractility in humans and mice

doi: 10.1016/j.lfs.2023.122037 43 MatsuzakiSPoulyJLCanisM