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Muscle is more than just what makes you look toned
Currently, two ongoing clinical trials are investigating the role of GLP-1 RAs in IBD management, that would lead to further knowledge: a French study (ID NCT05196958) evaluating the safety and efficacy of GLP-1 RAs in treatment of DM2 in overweight IBD patients (115), and an American study (ID NCT06774079) comparing the efficacy of GLP-1 RAs tirzepatide versus diet in CD patients (116)
The rationale for combining these two peptides is mechanistic complementarity
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Mitochondrial dysfunction, insulin resistance, and potential genetic implications
