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In the absence of phosphorylation, AANAT is immediately degraded by proteasomal proteolysis
Importantly, several NDD-associated genes, including GBA, GRN, and ATP13A2, are shared with lysosomal storage disorders, reinforcing lysosomal integrity as a critical determinant of neuronal health
86 WillardFSDourosJDGabeMBShowalterADWainscottDBSuterTMet al
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