Proceedings of the National Academy of Sciences of the United States of America 88 , 93609364 (1991)
If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature)
Briefly, the amplified IGF-1 fragment was inserted into the adenoviral vector, which contains the mouse cytomegalovirus (CMV) promoter, using the AdMax system
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