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However, these findings are preliminary and largely due to weight loss benefits, improved health markers, and psychological effects rather than the medication alone

This finding highlights a fundamental distinction that must be applied when interpreting the preclinical literature as a whole: the majority of studies reporting positive outcomes employed a preventive or co-treatment paradigm, in which the drug was administered prior to or concurrently with pathological induction

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As a result, millions of beneficiaries may become eligible for therapies that were previously out of reach