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The trigeminal route includes transport along different branches of the trigeminal nerve that innervate the nasal respiratory mucosa: the ethmoidal nerve originating from the ophthalmic nerve, as well as the posterior nasal branches and the nasopalatinal nerve originating from the maxillary nerve [42, 43]

Topical GHK-CU dosing Topical application suits facial rejuvenation, localized skin concerns, and maintenance protocols

Cell culture applications utilize concentrations of 10-50 M for effective senescent cell elimination, with administration durations typically 24-72 hours depending on experimental objectives and cellular models

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Ethics statement All experimental animals received proper care, and all procedures were conducted in accordance with the guidelines of the National Institutes of Health for the care and use of laboratory animals