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38,39 In the hippocampal tissue of type 2 diabetic mice, the expression of mitochondrial dynamin-related protein 1 (Drp1) increased, whereas inhibition of Drp1 restored neuronal function
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Additionally, the FDA recommends that these medications not be taken during pregnancy and be discontinued at least two months prior to pregnancy, because studies in rats, rabbits, and monkeys demonstrated that animals treated with these medications had higher rates of miscarriage, were born smaller, and were more likely to have birth defects
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