According to the data provided by the Synapse Database, As of November 22, 2023, there are 39 investigational drugs for the GIPR and GLP-1R target, including 24 indications, 29 R&D institutions involved, with related clinical trials reaching 154, and as many as 1328 patents
Additionally, Ozempic has demonstrated potential for weight loss in individuals with type II diabetes
However, comparisons between short and long term exposure of GLP-1R agonists in the presence of the GLP-1R antagonist Exendin-9, on neurite outgrowth, neuronal sensitivity and TRPV1 expression in thoracic and lumbosacral DRG are required, and will be the focus of future studies
Early CagriSema trials show weight loss that matches or exceeds these results at comparable time points
Current data do not always justify the use of Se in the treatment of HT, despite the fact that it leads to a decrease in the level of TPOAb and TgAb