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While the male longevity was not affected by the cIII or cV knockdown, females with cIII knockdown exhibited significantly decreased lifespan (Additional File 3: Fig
In addition, Caveolin-1 (Cav-1), a 21-kDa integral plasma membrane protein is a well-known negative regulator of eNOS activity in vascular endothelial cells 17,18,19,20,21,22
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