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PMC 431048

The observed activity level was consistent with the predicted value of 500 U L 1, confirming the reliability and validity of the RSM analysis under the specified experimental conditions

While it is not known if the impact on blood pressure was due to the medication or the participants weight loss, the lower blood pressure measures seen with tirzepatide rivaled what is seen for many hypertension medications. The current research was a planned sub-study including 600 of the participants from the SURMOUNT-1 weight loss study to determine if there was an effect on blood pressure

Interactions of melphalan with glutathione and the role of glutathione S-transferase [PMID: 8820431] Laboratory literature summary: Interactions of melphalan with glutathione and the role of glutathione S-transferase

Selectivity was reported against COMT and against the SAM-dependent DNA and protein methyltransferases DNMT1 and PRMT3