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This muscle loss carries important consequences: reduced metabolic rate, decreased strength, and potentially accelerated weight regain once dietary restriction ends

Understanding its mechanism of action helps explain why dietary modifications become particularly important during treatment

and activating GCGR to promote lipolysis and energy expenditure while regulating hepatic glucose and lipid metabolism to reduce fat accumulation

The article notes that impairment can affect how both agents are handled and increases accumulation risk, and that the NAD salvage pathway involves liver enzymes

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