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The SOUL cardiovascular outcomes trial (CVOT) demonstrated a 14% relative reduction in risk of MACE in patients treated with Rybelsus 14 mg orally once daily for approximately 5 years compared to those who received placebo

Cardiac Catheterization Policy number: M.33 Summary: Covers right, left, or combined heart catheterization when clinically indicated for diagnosis or treatment planning of cardiac conditions, while excluding non-indicated uses such as routine angioplasty or electrophysiologic studies

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Their use in this context is best considered as an adjunct option for select patients

Therapeutic scope and regulatory status Afamelanotide is approved for EPP to reduce phototoxicity