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The 2008 Lancet Phase IIb trial reported 10.6% mean weight loss on tesofensine 1mg daily

This doesn't necessarily mean DSIP is dangerous, but it does mean comprehensive safety evaluation hasn't been completed

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Vascular endothelial growth factor (VEGF) delivery approaches in regenerative medicine

Consistently, the motor nerve conduction study confirmed the absence of demyelinated processes in the tail caudal nerves after spinal cord injury (the CMAP showed normal biphasic potentials, similar amplitudes, and similar conduction velocities in all of the rats) (Table 4)