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doi: 10.1016/j.intimp.2020.107061 250 YangSYinWDingYLiuF

Anti-Aging:

When the body is in a state of hypoxia, infection, intense exercise, etc, and the cells demand for ATP increases, pyruvate and NADH tends to be directly catalyzed by lactate dehydrogenase (LDH) to produce lactate, rather than entering the mitochondria to participate in the tricarboxylic acid cycle (TCA)

309 They often express high levels of ABC transporters (e.g., ABCG2), ALDH activity, and robust DNA repair machinery, making them inherently resistant to chemotherapy and radiotherapy