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Plateaus often reflect metabolic stabilisation rather than treatment failure

Zhenqi Liu to unpack the hidden risks of rapid weight lossincluding muscle loss, metabolic slowdown, and rebound fat gainand how to avoid them

Mounjaro vs Wegovy: Understanding the Medications Before looking at the switching process, let's recap the basics GLP-1 receptor agonist GIP receptor agonist Slows gastric emptying GLP-1 receptor agonist Regulates blood sugar Reduces appetite Chronic weight management (Licensed specifically for weight loss) Starting dose: 2.5mg Maximum: 15mg weekly Starting dose: 0.25mg Maximum: 2.4mg weekly May be more effective at higher doses NICE approved Newer medication with promising results Well-established efficacy NICE approved for weight management Diarrhoea Decreased appetite Vomiting Constipation Vomiting Diarrhoea Constipation Abdominal pain Higher monthly cost Limited NHS availability Private prescription required More affordable option Available on NHS in some areas Private options available Multiple Endocrine Neoplasia syndrome type 2 Severe gastroparesis Pregnancy and breastfeeding Multiple Endocrine Neoplasia syndrome type 2 Severe gastroparesis Pregnancy and breastfeeding Important: This comparison is for educational purposes only

Mild thermogenic effect Pre-clinical data show bupropion can raise oxygen consumption and heat production (Pharmacol Biochem Behav 2004)

Over 16 million Americans use GLP-1 medications for weight management, yet many delay treatment due to insurance barriers and high out-of-pocket costs