Though glutathione makes it's fame being a "master antioxidant" the main use case these days is for its skin-lightening and evening effect
Controlled human trials exist, but they're limited in size, focused mostly on topical cosmetic use, and usually last only a few weeks or months. That means a lot of the exciting claims, especially around gene expression, systemic repair, and anti-aging effects, haven't been confirmed in large-scale human studies
Vitamin B12 Deficiency and the Nervous System: Beyond Metabolic DecompensationComparing Biological Models and Gaining New Insights into Molecular and Cellular Mechanisms
These DAMPs draw in and activate immune cells, driving ICD
For supplementation compliance, participants in placebo, CIT-malate, and GSH+ CIT all reported a compliance rate of 100%