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The STEP clinical trial programme, published in the New England Journal of Medicine, demonstrated average weight reductions of approximately 15% of body weight over 68 weeks in adults without type 2 diabetes
This review was mainly summarized on the basis of research data, and therefore had limitations in many aspects: (1) Although we already knew that GLP-1RA inhibited the activation of microglia and promoted their polarization towards the M2 type, the regulatory mechanism of their induction of polarization in naive CD4 + T cells was still unknown, in particular their impact on the proportion of Tregs subtypes in T cells at the sites of infarct lesion
Some people will gain more than that back to their original weight over time
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