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In addition, the characterized LASSS treatment did not stimulate autolysis of HGF as monitored by SDS-PAGE for degradation of 60-kDa -chain and 90-kDa proform of recombinant HGF incubated with LASSS (at 1:8000) at 25 for 2 h (see supplementary Figure 1b), providing another important basis for the availability of LASSS-HGF
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Moreover, TG2 mediates HPV-E7 and eIF4E-BP polyamination, which affects their respective interactions with Rb and Raptor to suppress HPV-E7 and selectively control translation 7,8
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